KC ranks No. 11 among Midwest startup cities, holding its spot thanks to funding wins amid VC slowdown

August 10, 2023  |  Matthew Gwin

A healthy dose of recent funding events kept Kansas City in the No. 11 spot in the 2023 edition of M25’s annual ranking of Midwest startup cities, said Victor Gutwein, founder and managing partner at M25.

The comprehensive report explores how metropolitan areas across the Midwest are performing relative to each other based on startup activity, access to resources, and business climate.

Click here to view the complete rankings from M25.

Victor Gutwein, M25

Gutwein pointed to raises from PayIt, Sailes, Free From Market, Orange EV, and Redeem as positive activity within the local startup ecosystem, adding that Kansas City outperformed higher-ranked cities like Saint Louis and Indianapolis in that area.

“Kansas City has had a lot of relatively big recent wins,” Gutwein said. “That’s what is keeping the city strong.”

Click here to check out M25’s Kansas City breakdown.

Having regionally-focused venture capital firms — like the KCRise Fund, which closed its $34 million Fund III earlier this year — separates Kansas City from many other Midwestern cities, Gutwein added.

“They raised that even when the economy is down,” Gutwein said. “That is making it clear people are seeing good results, and they’re seeing a reason to invest in Kansas City. … It’s actually very, very rare to find such a relatively small, geographic-focused venture fund that’s having so much success.”

Another big win in Kansas City’s column: Homegrown Rx Savings Solutions’ exit to McKesson Corporation in a deal reportedly valued at $875 million. The acquisition was finalized in November.

Beyond the news event of Rx Savings’ sale, the move could have a meaningful ripple effect, Gutwein said.

“It was acquired by McKesson, which also had the major acquisition of CoverMyMeds back in 2017 in Columbus, Ohio, and that was a huge catalyst for that ecosystem,” he said. “KC might continue to see boosts from this for years to come.”

RELATED: After exit: How Rx Savings Solutions’ $875M sale could mean opportunity for KC (even if details aren’t yet clear)

As the broader economy slows down, venture capital invested in Midwest startups has returned to pre-pandemic levels, though Gutwein cautioned against extreme concern.

“I’m not too worried about our companies,” he said of startups in the Heartland. “I think there was just a really exceptional amount of capital coming in during that two-year period from mid-2020 to mid-2022. That was an exceptional point in time, and now we’re back to a new normal. It may feel tight and constricted, but it’s not too bad in the scheme of things.”

Some of the funding activity during that time frame was unlikely to be sustainable, Gutwein added, noting that the prevailing sentiment in the VC industry is that funding will stay low temporarily but recover within a couple years.

While startups adjust to lower and less frequent cash flows, Midwestern companies have an advantage over coastal startups, Gutwein said.

“A lot of our companies have adjusted to be more profitable,” he said. “They didn’t have crazy high burn rates anyway. It’s pretty encouraging to see our companies still growing, still hiring, and still finding a lot of success. … That’s one area where I think the Midwest has an advantage. When the capital is free-flowing, it’s great; but when it’s not, our companies don’t rely on capital too much.”

Click here to read Gutwein’s M25 commentary on the rankings.

Funding from the State Small Business Credit Initiative Program (SSBCI) — an outgrowth of the Biden Administration’s American Rescue Plan — has been a key variable across startup ecosystems as states allocate the resources from the federal government differently, Gutwein noted.

Wichita city skyline

He described Kansas as having an aggressive approach, which helped Wichita surge up the rankings to No. 29, up 13 spots from last year.

RELATED: ‘Every business matters, every job matters’: How $69M in federal funds is already boosting KS entrepreneurs

“That has also catalyzed a lot of angel [investment] activity in the city,” Gutwein said. “That’s going to result in more startups getting funded, more people moving there, or leaving a larger company there and starting a company.”

Seed rounds from WorkTorch and Plot could be a harbinger of more funding coming to the Wichita area, Gutwein added.

“That’s not something you used to see in Wichita, so I think that’s encouraging,” he said. “It’s a good sign, and that happened before even most of the SSBCI funding.”

RELATED: Trio of Kansas City startups among Missouri’s latest equity investments; $2.4M awarded in July

On the Missouri side of the state line, Columbia climbed yet another spot, up to No. 21.

EquipmentShare — on the heels of a $290 million Series E round — continues to power the mid-Missouri college town’s growth, causing folks from across the country to take notice, Gutwein said.

“That’s been one of the more interesting ecosystems to watch lately,” he said. “I hardly paid attention to [Columbia] when I started at M25 in 2015. Now, it’s somewhere you can’t ignore. … It’s one that people nationally have heard of and seen some of the activity.”

RELATED: EquipmentShare named to Y Combinator top companies list as it expands across Heartland, opens Ohio center

Fellow college town Manhattan made its first appearance in the rankings, debuting at No. 43, 14 spots ahead of nearby Topeka at No. 57.

Though the Manhattan startup ecosystem is relatively small, it benefits from having Kansas State University in the city, Gutwein said, adding that the Little Apple proved it belongs on the list.

“It definitely deserves to be compared and ranked and analyzed,” Gutwein said, “so that was very validating.”

[adinserter block="4"]

2023 Startups to Watch

    stats here

    Related Posts on Startland News

    A St. Joe CEO handed him a franchise after graduation; two years later, the risk is paying off 

    By Tommy Felts | October 17, 2025

    Spencer Engelman’s expectations for his post-college career were shredded by an offer he couldn’t refuse. The Northwest Missouri State University graduate was awarded a business of his own — minus the franchise fee — by a veteran entrepreneur who had visited one of his classes. “It’s a crazy opportunity,” said Engelman, who now operates a DocuLock…

    What a catch: Kansas City fandom creates custom appeal for taco-loving cartoonist vibe

    By Tommy Felts | October 17, 2025

    Drawing from Kansas City’s spotlight moments — whether trendy and new or iconic and timeless — W. Dave Keith balances a quirky aesthetic with a practical focus on what will actually sell. “I’ve slowly learned that if I want to make money off this business, I need to make stuff that people want to buy,”…

    Power through purpose: How a winding journey led this eco devo steward to deep-rooted impact

    By Tommy Felts | October 17, 2025

    Editor’s note: The following story was written and first published by the Economic Development Corporation of Kansas City, Missouri (EDCKC). Click here to read the original story. [divide] Going behind the scenes of CCED with the people who make it happen Some people are drawn to city-building because of the bricks and steel, the architecture, the skyline, the…

    Missouri’s weapon in the AI race with China: KC tech companies, says GOP lawmaker

    By Tommy Felts | October 16, 2025

    As artificial intelligence reshapes the way Kansas City works, civic and elected leaders want to ensure small businesses and the region’s tech community have seats at the table. Federal regulation could help, said Eric Schmitt. “For me, [it’s about] making sure that the big tech companies don’t block out a lot of the innovators, say…